Nanostructured micronized solid dispersion of crystalline-amorphous metronidazole embedded in amorphous polymer matrix prepared by nano spray drying

• Metronidazol-polymer composites were prepared by nano spray drying. In the solid dispersion metronidazol was crystalline and amorphous in polymer matrix. Melting point decrease phenomena observed DSC measurement. Peak broadening XRD analysis. The composite microparticles nanostructured. this study metronidazole drug encapsulated hydroxypropyl methylcellulose polyvinylpyrrolidone polymers from solutions using drying technology. influence of process parameters formulation variables investigated on product morhology structure, production yield entrapment efficiency. use surface active admixtures (polyvinyl alcohol, Tween-80 Pluronic F68) increased substantially. entrapped partially state both as confirmed powder X-ray diffraction measurements. with degree crystallinity between 50.2 81.0%, 35.0 50.0% (with respect to content). differential scanning calorimetry bulk dried products. indicated measurements, which could be result formation small crystallites. TEM images showed beside larger crystals (200–400 nm) a fraction smaller (20–50 nm diameter), are good correlation calculated coherent scattering domain sizes 19–87 based data. drug-polymer produced identified crystalline-amorphous nanostructured micronized dispersions.